Relevant publications

Parejo-Alonso et al. ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells. BioRxiv. doi: Preprint.

Martín-Rubio et al. Metabolic determinants of stemness in medulloblastoma.World J Stem Cells 2022; 14(8): 587-598. [DOI: 10.4252/wjsc.v14.i8.587]

Parejo-Alonso et al. PPAR-delta acts as a metabolic master checkpoint for metastasis in pancreatic cancer. BioRxiv. Preprint

Royo-García et al. Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer. World J Stem Cells 2021; 13(9): 1307-1317

Chisari et al. Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types. Front Pharmacol 2021 12:723798.

Courtois, de Luxán-Delgado et al. Inhibition of mitochondrial dynamics preferentially targets pancreatic cancer cells with enhanced tumorigenic and invasive potential. Cancers 2021; 13(4):698

Espiau-Romera et al. Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification. J. Clin. Med. 2020; 9, 4128

Jagust et al. Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells. World J Stem Cells 2020; 12(11): 1410-1428

Bokil A, Sancho P. Mitochondrial determinants of chemoresistance. Cancer Drug Resist 2019 Jul 25

Jagust P et al. Metabolism-based therapeutic strategies targeting cancer stem cells. Front Pharmacol 2019; 10:203.

Heeschen C, Sancho P. More challenges ahead-metabolic heterogeneity of pancreatic cancer stem cells. Mol Cell Oncol 2016; 3(2):e1105353.

Sancho P et al. Hallmarks of Cancer Stem Cells Metabolism. Br J Cancer 2016; 114(12):1305.

Sancho P et al. The ever-changing landscape of pancreatic cancer stem cells. Pancreatology 2016;16(4):489.

Sancho P et al. 2015. MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells. Cell Metabolism 2015; 22(4):590.

Hermann PC*, Sancho P* et al. Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice. Gastroenterology 2014; 147(5): 1119.


Alonso-Nocelo et al. Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma. Gut 2022;gutjnl-2021-325564. doi: 10.1136/gutjnl-2021-325564.

Valle et al. Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells. Nat Commun 2020; 11, 5265

Alcalá et al. ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity. Nat Commun 2020; 11, 2682

Demircioglu et al. Cancer associated fibroblast FAK regulates malignant cell metabolism. Nat Commun 2020; 11, 1290

Sainz Jr B et al.Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartmentGut 2015; 64(12):1921.

Lonardo E et al. Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies. J Vis Exp. 2015; (100):e52801.

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